Drug interactions
Apomorphine + Bromocriptine
Severity: Moderate
Apomorphine and Bromocriptine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are dopamine agonists, so combined use increases dopaminergic effects. This may add efficacy in Parkinson disease but also increases nausea, orthostatic hypotension, somnolence, hallucinations and dyskinesia.
What this interaction means in plain words
Apomorphine and Bromocriptine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Bromocriptine belongs to Central Nervous System.
Why it happens
Additive dopamine receptor agonism.
What to do
Monitor blood pressure including orthostatic readings, and watch for nausea, sleepiness and psychiatric effects. Lower the dose of one agent if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Bromocriptine?
MediHelp rates the interaction as moderate. Apomorphine and Bromocriptine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are dopamine agonists, so combined use increases dopaminergic effects. This may add efficacy in Parkinson disease but also increases nausea, orthostatic hypotension, somnolence, hallucinations and dyskinesia.
How serious is the interaction between Apomorphine and Bromocriptine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including orthostatic readings, and watch for nausea, sleepiness and psychiatric effects. Lower the dose of one agent if adverse effects emerge.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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