Drug interactions
Apomorphine + Clomipramine
Severity: Moderate
Apomorphine and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, and apomorphine can also cause hypotension and orthostatic dizziness. Clomipramine may add to these effects and increase the risk of drowsiness and falls.
What this interaction means in plain words
Apomorphine and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Clomipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects (pharmacodynamic).
What to do
Monitor for sedation and orthostatic hypotension, particularly when starting or increasing doses. Counsel patients on rising slowly and avoiding driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Clomipramine?
MediHelp rates the interaction as moderate. Apomorphine and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, and apomorphine can also cause hypotension and orthostatic dizziness. Clomipramine may add to these effects and increase the risk of drowsiness and falls.
How serious is the interaction between Apomorphine and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension, particularly when starting or increasing doses. Counsel patients on rising slowly and avoiding driving until the response is known.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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