Drug interactions
Apomorphine + Clorazepate
Severity: Moderate
Apomorphine and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine can cause somnolence, dizziness and hypotension, and these effects may be amplified by a benzodiazepine. Falls and excessive sedation are the main concerns.
What this interaction means in plain words
Apomorphine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Clorazepate belongs to Central Nervous System.
Why it happens
Additive CNS depressant and hypotensive effects via pharmacodynamic synergy.
What to do
Monitor sedation and blood pressure, especially after the first doses or dose increases. Reduce doses if daytime somnolence or orthostasis occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Clorazepate?
MediHelp rates the interaction as moderate. Apomorphine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine can cause somnolence, dizziness and hypotension, and these effects may be amplified by a benzodiazepine. Falls and excessive sedation are the main concerns.
How serious is the interaction between Apomorphine and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, especially after the first doses or dose increases. Reduce doses if daytime somnolence or orthostasis occurs.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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