Drug interactions
Apomorphine + Desflurane
Severity: Moderate
Apomorphine and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine can cause somnolence, nausea and orthostatic hypotension, and desflurane adds CNS depression and vasodilation. The combination may deepen sedation and worsen hypotension during and after anesthesia.
What this interaction means in plain words
Apomorphine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Desflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression and vasodilatory hypotension from dopamine agonism and anesthetic effect.
What to do
Monitor blood pressure and depth of anesthesia and titrate desflurane accordingly. Manage postoperative orthostasis cautiously and keep antiemetic choice free of dopamine antagonists that antagonize apomorphine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Desflurane?
MediHelp rates the interaction as moderate. Apomorphine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine can cause somnolence, nausea and orthostatic hypotension, and desflurane adds CNS depression and vasodilation. The combination may deepen sedation and worsen hypotension during and after anesthesia.
How serious is the interaction between Apomorphine and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and depth of anesthesia and titrate desflurane accordingly. Manage postoperative orthostasis cautiously and keep antiemetic choice free of dopamine antagonists that antagonize apomorphine.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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