Drug interactions
Apomorphine + Dexmedetomidine
Severity: Moderate
Apomorphine and Dexmedetomidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and hypotension. Used together, sedation and blood pressure lowering may be greater than with either drug alone, particularly in elderly or hemodynamically fragile patients.
What this interaction means in plain words
Apomorphine and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Dexmedetomidine belongs to Central Nervous System.
Why it happens
Additive central sedative effects and additive hypotensive effects (alpha-2 agonism plus dopaminergic vasodilation).
What to do
Monitor sedation level and blood pressure, including orthostatic changes, and titrate dexmedetomidine to the lowest effective rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexmedetomidine
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Dexmedetomidine?
MediHelp rates the interaction as moderate. Apomorphine and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and hypotension. Used together, sedation and blood pressure lowering may be greater than with either drug alone, particularly in elderly or hemodynamically fragile patients.
How serious is the interaction between Apomorphine and Dexmedetomidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and blood pressure, including orthostatic changes, and titrate dexmedetomidine to the lowest effective rate.
What other medicines interact with Dexmedetomidine?
MediHelp also lists interactions of Dexmedetomidine with, for example, Buprenorphine long-acting, Calcium / magnesium / potassium / sodium oxybates, Dextromoramide. The full list is on the Dexmedetomidine page.
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