Drug interactions
Apomorphine + Hydroxyzine
Severity: Moderate
Apomorphine and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine can add to the sedation and hypotension seen with apomorphine, and both drugs have been linked to QT prolongation. The risk of dizziness, falls and arrhythmia is higher in older patients and those with cardiac disease. Hydroxyzine is also a dopamine-blocking-free antihistamine but may still reduce alertness.
What this interaction means in plain words
Apomorphine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Additive CNS depression, orthostatic hypotension and QT prolongation.
What to do
Monitor blood pressure, sedation and ECG in patients with QT risk factors. Use the lowest effective hydroxyzine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Hydroxyzine?
MediHelp rates the interaction as moderate. Apomorphine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine can add to the sedation and hypotension seen with apomorphine, and both drugs have been linked to QT prolongation. The risk of dizziness, falls and arrhythmia is higher in older patients and those with cardiac disease. Hydroxyzine is also a dopamine-blocking-free antihistamine but may still reduce alertness.
How serious is the interaction between Apomorphine and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, sedation and ECG in patients with QT risk factors. Use the lowest effective hydroxyzine dose.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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