Drug interactions
Apomorphine + Indacaterol-glycopyrronium
Severity: Moderate
Apomorphine and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine can prolong the QT interval, and long-acting beta2-agonists like indacaterol may also affect repolarization and heart rate. Together they may modestly increase the risk of ventricular arrhythmia, especially with other risk factors.
What this interaction means in plain words
Apomorphine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive QT prolongation and beta2-agonist related hypokalemia and tachycardia.
What to do
Check baseline ECG and correct potassium and magnesium before combining. Monitor for palpitations, syncope and QTc changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Apomorphine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine can prolong the QT interval, and long-acting beta2-agonists like indacaterol may also affect repolarization and heart rate. Together they may modestly increase the risk of ventricular arrhythmia, especially with other risk factors.
How serious is the interaction between Apomorphine and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium before combining. Monitor for palpitations, syncope and QTc changes.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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