Drug interactions
Apomorphine + Loperamide
Severity: Moderate
Apomorphine and Loperamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, and combining them may increase the risk of torsades de pointes. The risk is greatest with high loperamide doses or other risk factors.
What this interaction means in plain words
Apomorphine and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Loperamide belongs to Gastrointestinal Tract.
Why it happens
Additive prolongation of cardiac repolarisation through effects on cardiac ion channels.
What to do
Keep loperamide at the recommended dose and correct electrolyte disturbances. Consider baseline and follow-up ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Loperamide?
MediHelp rates the interaction as moderate. Apomorphine and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, and combining them may increase the risk of torsades de pointes. The risk is greatest with high loperamide doses or other risk factors.
How serious is the interaction between Apomorphine and Loperamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep loperamide at the recommended dose and correct electrolyte disturbances. Consider baseline and follow-up ECG in patients with cardiac risk factors.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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