Drug interactions
Apomorphine + Lurasidone
Severity: Major
Apomorphine and Lurasidone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine is a dopamine agonist used in Parkinson disease, while lurasidone blocks dopamine D2 receptors. The two have opposing effects, so apomorphine may be less effective and parkinsonian symptoms may worsen. Additive hypotension may also occur.
What this interaction means in plain words
Apomorphine and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apomorphine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between D2 receptor blockade by lurasidone and dopamine agonism by apomorphine.
What to do
Avoid the combination if possible in patients with Parkinson disease. If antipsychotic therapy is essential, consider an agent with less D2 blockade and monitor motor symptoms and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Lurasidone?
MediHelp rates the interaction as major. Apomorphine and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apomorphine is a dopamine agonist used in Parkinson disease, while lurasidone blocks dopamine D2 receptors. The two have opposing effects, so apomorphine may be less effective and parkinsonian symptoms may worsen. Additive hypotension may also occur.
How serious is the interaction between Apomorphine and Lurasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible in patients with Parkinson disease. If antipsychotic therapy is essential, consider an agent with less D2 blockade and monitor motor symptoms and blood pressure.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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