Drug interactions
Apomorphine + Nitroglycerin
Severity: Moderate
Apomorphine and Nitroglycerin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine can cause orthostatic hypotension and syncope. Nitroglycerin is a vasodilator, so the combination can produce additive blood pressure falls.
What this interaction means in plain words
Apomorphine and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Nitroglycerin belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive effects of apomorphine and nitrates.
What to do
Monitor blood pressure and have the patient lie down when taking sublingual nitroglycerin. Counsel on rising slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Other interactions of Nitroglycerin
- Avanafil + Nitroglycerin Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Nitroglycerin + Sildenafil Contraindicated
- Nitroglycerin + Tadalafil Contraindicated
- Nitroglycerin + Vardenafil Contraindicated
- Dihydroergotamine intranasal + Nitroglycerin Major
Frequently asked questions
Can I take Apomorphine with Nitroglycerin?
MediHelp rates the interaction as moderate. Apomorphine and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine can cause orthostatic hypotension and syncope. Nitroglycerin is a vasodilator, so the combination can produce additive blood pressure falls.
How serious is the interaction between Apomorphine and Nitroglycerin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and have the patient lie down when taking sublingual nitroglycerin. Counsel on rising slowly.
What other medicines interact with Apomorphine?
MediHelp also lists interactions of Apomorphine with, for example, Alosetron, Cisapride, Dolasetron. The full list is on the Apomorphine page.
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