Drug interactions
Apomorphine + Oxaliplatin
Severity: Moderate
Apomorphine and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combined use may raise the risk of torsades de pointes. Risk is greater with electrolyte disturbances, which are common with oxaliplatin-related vomiting or diarrhea.
What this interaction means in plain words
Apomorphine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Oxaliplatin belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium before and during treatment. Consider alternatives if the QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Oxaliplatin?
MediHelp rates the interaction as moderate. Apomorphine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so combined use may raise the risk of torsades de pointes. Risk is greater with electrolyte disturbances, which are common with oxaliplatin-related vomiting or diarrhea.
How serious is the interaction between Apomorphine and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before and during treatment. Consider alternatives if the QTc is prolonged.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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