Drug interactions
Apomorphine + Solifenacin
Severity: Moderate
Apomorphine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine has been associated with QT prolongation and solifenacin has a dose-related QT effect, so combined use may add to arrhythmia risk. Apomorphine can also cause hypotension and nausea.
What this interaction means in plain words
Apomorphine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Possible additive QT prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium in patients with other QT risk factors; limit the solifenacin dose to the lowest effective one.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Solifenacin?
MediHelp rates the interaction as moderate. Apomorphine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine has been associated with QT prolongation and solifenacin has a dose-related QT effect, so combined use may add to arrhythmia risk. Apomorphine can also cause hypotension and nausea.
How serious is the interaction between Apomorphine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium in patients with other QT risk factors; limit the solifenacin dose to the lowest effective one.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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