Drug interactions
Aprepitant + Bortezomib
Severity: Moderate
Aprepitant and Bortezomib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib is metabolized partly by CYP3A4, so aprepitant may raise its exposure. Clinically significant changes are not well established, but toxicity such as neuropathy or cytopenias could be greater.
What this interaction means in plain words
Aprepitant and Bortezomib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Bortezomib belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, a metabolic pathway of bortezomib.
What to do
Monitor for bortezomib toxicity including neuropathy, cytopenias and gastrointestinal effects. Adjust the bortezomib dose per labeling if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Aprepitant with Bortezomib?
MediHelp rates the interaction as moderate. Aprepitant and Bortezomib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bortezomib is metabolized partly by CYP3A4, so aprepitant may raise its exposure. Clinically significant changes are not well established, but toxicity such as neuropathy or cytopenias could be greater.
How serious is the interaction between Aprepitant and Bortezomib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bortezomib toxicity including neuropathy, cytopenias and gastrointestinal effects. Adjust the bortezomib dose per labeling if toxicity develops.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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