Drug interactions
Aprepitant + Brexpiprazole
Severity: Moderate
Aprepitant and Brexpiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and can raise brexpiprazole exposure. The increase is more important in patients who also take a CYP2D6 inhibitor or are CYP2D6 poor metabolizers.
What this interaction means in plain words
Aprepitant and Brexpiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Brexpiprazole belongs to Central Nervous System.
Why it happens
Aprepitant inhibits CYP3A4, reducing brexpiprazole clearance.
What to do
Reduce brexpiprazole to a quarter of the usual dose if the patient is also on a CYP2D6 inhibitor. Otherwise monitor for akathisia, sedation, and orthostasis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Aprepitant with Brexpiprazole?
MediHelp rates the interaction as moderate. Aprepitant and Brexpiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor and can raise brexpiprazole exposure. The increase is more important in patients who also take a CYP2D6 inhibitor or are CYP2D6 poor metabolizers.
How serious is the interaction between Aprepitant and Brexpiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce brexpiprazole to a quarter of the usual dose if the patient is also on a CYP2D6 inhibitor. Otherwise monitor for akathisia, sedation, and orthostasis.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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