Drug interactions
Aprepitant + Cinacalcet
Severity: Minor
Aprepitant and Cinacalcet: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is metabolized by CYP3A4, CYP2D6 and CYP1A2. Aprepitant may modestly increase cinacalcet levels, which could add to nausea, vomiting and hypocalcemia.
What this interaction means in plain words
Aprepitant and Cinacalcet have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Cinacalcet belongs to Miscellaneous.
Why it happens
Aprepitant inhibits CYP3A4, one of several pathways of cinacalcet metabolism.
What to do
No dose change is generally required. Monitor serum calcium and gastrointestinal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Aprepitant with Cinacalcet?
MediHelp rates the interaction as minor. Aprepitant and Cinacalcet have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cinacalcet is metabolized by CYP3A4, CYP2D6 and CYP1A2. Aprepitant may modestly increase cinacalcet levels, which could add to nausea, vomiting and hypocalcemia.
How serious is the interaction between Aprepitant and Cinacalcet?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required. Monitor serum calcium and gastrointestinal symptoms.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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