Drug interactions
Aprepitant + Clomipramine
Severity: Minor
Aprepitant and Clomipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is metabolized partly by CYP3A4 alongside CYP2C19 and CYP2D6. Aprepitant may raise its levels, increasing the risk of anticholinergic effects, sedation, seizures and conduction abnormalities.
What this interaction means in plain words
Aprepitant and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Clomipramine belongs to Central Nervous System.
Why it happens
Aprepitant inhibits CYP3A4, a secondary pathway of clomipramine metabolism.
What to do
No routine dose change is needed for short aprepitant courses. Monitor for sedation, anticholinergic effects and palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Aprepitant with Clomipramine?
MediHelp rates the interaction as minor. Aprepitant and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clomipramine is metabolized partly by CYP3A4 alongside CYP2C19 and CYP2D6. Aprepitant may raise its levels, increasing the risk of anticholinergic effects, sedation, seizures and conduction abnormalities.
How serious is the interaction between Aprepitant and Clomipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for short aprepitant courses. Monitor for sedation, anticholinergic effects and palpitations.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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