Drug interactions
Aprepitant + Crizotinib
Severity: Moderate
Aprepitant and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a CYP3A substrate and a moderate CYP3A inhibitor, and aprepitant is also a CYP3A4 substrate and moderate inhibitor. Co-administration may raise concentrations of both drugs and increase adverse effects such as QT prolongation, bradycardia, hepatotoxicity and nausea.
What this interaction means in plain words
Aprepitant and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Crizotinib belongs to Oncology.
Why it happens
Mutual inhibition of CYP3A4 metabolism by the two drugs may increase exposure to each.
What to do
Monitor ECG and electrolytes, heart rate and liver function when the combination is needed. Watch for adverse effects of either drug and consider alternative antiemetics if problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Aprepitant with Crizotinib?
MediHelp rates the interaction as moderate. Aprepitant and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a CYP3A substrate and a moderate CYP3A inhibitor, and aprepitant is also a CYP3A4 substrate and moderate inhibitor. Co-administration may raise concentrations of both drugs and increase adverse effects such as QT prolongation, bradycardia, hepatotoxicity and nausea.
How serious is the interaction between Aprepitant and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, heart rate and liver function when the combination is needed. Watch for adverse effects of either drug and consider alternative antiemetics if problems arise.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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