Drug interactions
Aprepitant + Dapsone
Severity: Minor
Aprepitant and Dapsone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapsone is partly metabolised by CYP3A4, so aprepitant may raise its levels slightly. This could increase dose-related hemolysis or methemoglobinemia, though clinical significance is unclear.
What this interaction means in plain words
Aprepitant and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Dapsone belongs to Anti Bacterial.
Why it happens
Aprepitant inhibits CYP3A4, slightly reducing dapsone clearance.
What to do
No empiric adjustment is needed; monitor for hemolysis or methemoglobinemia in patients on prolonged therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Aprepitant with Dapsone?
MediHelp rates the interaction as minor. Aprepitant and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dapsone is partly metabolised by CYP3A4, so aprepitant may raise its levels slightly. This could increase dose-related hemolysis or methemoglobinemia, though clinical significance is unclear.
How serious is the interaction between Aprepitant and Dapsone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric adjustment is needed; monitor for hemolysis or methemoglobinemia in patients on prolonged therapy.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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