Drug interactions
Aprepitant + Daridorexant
Severity: Moderate
Aprepitant and Daridorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant raises daridorexant exposure by inhibiting CYP3A4. This increases the risk of next-day somnolence and impaired driving.
What this interaction means in plain words
Aprepitant and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Daridorexant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated daridorexant metabolism by aprepitant.
What to do
Limit daridorexant to a maximum of 25 mg per night during coadministration. Counsel on next-day drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Aprepitant with Daridorexant?
MediHelp rates the interaction as moderate. Aprepitant and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant raises daridorexant exposure by inhibiting CYP3A4. This increases the risk of next-day somnolence and impaired driving.
How serious is the interaction between Aprepitant and Daridorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit daridorexant to a maximum of 25 mg per night during coadministration. Counsel on next-day drowsiness.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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