Drug interactions
Aprepitant + Eplerenone
Severity: Moderate
Aprepitant and Eplerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eplerenone is a sensitive CYP3A4 substrate, and aprepitant may increase its exposure. This raises the risk of hyperkalemia, especially in patients with renal impairment or on other potassium-raising drugs.
What this interaction means in plain words
Aprepitant and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Eplerenone belongs to Cardiovascular.
Why it happens
Aprepitant inhibits CYP3A4, decreasing eplerenone metabolism.
What to do
Monitor serum potassium and renal function during aprepitant use, and reduce the eplerenone dose if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Aprepitant with Eplerenone?
MediHelp rates the interaction as moderate. Aprepitant and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eplerenone is a sensitive CYP3A4 substrate, and aprepitant may increase its exposure. This raises the risk of hyperkalemia, especially in patients with renal impairment or on other potassium-raising drugs.
How serious is the interaction between Aprepitant and Eplerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function during aprepitant use, and reduce the eplerenone dose if potassium rises.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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