Drug interactions
Aprepitant + Etonogestrel
Severity: Moderate
Aprepitant and Etonogestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant may alter hormonal contraceptive exposure, and labeling advises that its efficacy can be reduced during and for a period after treatment. Reduced contraceptive reliability may result in unintended pregnancy.
What this interaction means in plain words
Aprepitant and Etonogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Etonogestrel belongs to Endocrine.
Why it happens
Aprepitant is a CYP3A4 substrate that induces other enzymes such as CYP2C9, and the net effect on progestin exposure is inconsistent.
What to do
Advise an additional non-hormonal contraceptive method during aprepitant treatment and for about one month after the last dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Etonogestrel
Frequently asked questions
Can I take Aprepitant with Etonogestrel?
MediHelp rates the interaction as moderate. Aprepitant and Etonogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant may alter hormonal contraceptive exposure, and labeling advises that its efficacy can be reduced during and for a period after treatment. Reduced contraceptive reliability may result in unintended pregnancy.
How serious is the interaction between Aprepitant and Etonogestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during aprepitant treatment and for about one month after the last dose.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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