Drug interactions
Aprepitant + Etravirine
Severity: Moderate
Aprepitant and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may lower aprepitant concentrations, while aprepitant may modestly raise etravirine exposure. The net effect on aprepitant could reduce antiemetic efficacy, whereas etravirine changes are probably small.
What this interaction means in plain words
Aprepitant and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4 (lowering aprepitant), and aprepitant inhibits CYP3A4 (possibly raising etravirine).
What to do
Monitor for breakthrough nausea and vomiting and ensure guideline-based antiemetic combination therapy. No empiric etravirine dose change is usually needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Aprepitant with Etravirine?
MediHelp rates the interaction as moderate. Aprepitant and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may lower aprepitant concentrations, while aprepitant may modestly raise etravirine exposure. The net effect on aprepitant could reduce antiemetic efficacy, whereas etravirine changes are probably small.
How serious is the interaction between Aprepitant and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting and ensure guideline-based antiemetic combination therapy. No empiric etravirine dose change is usually needed.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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