Drug interactions
Aprepitant + Iloperidone
Severity: Moderate
Aprepitant and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is metabolized by CYP3A4 and CYP2D6 and prolongs the QT interval. Aprepitant may raise iloperidone concentrations, increasing QT and sedation risk, and iloperidone may slightly raise aprepitant levels.
What this interaction means in plain words
Aprepitant and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Iloperidone belongs to Central Nervous System.
Why it happens
Aprepitant inhibits CYP3A4, reducing iloperidone clearance, with possible reciprocal CYP3A inhibition by iloperidone.
What to do
Monitor for sedation, orthostasis and QT prolongation, with ECG and electrolytes if there are other risk factors. Consider reducing iloperidone dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Aprepitant with Iloperidone?
MediHelp rates the interaction as moderate. Aprepitant and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is metabolized by CYP3A4 and CYP2D6 and prolongs the QT interval. Aprepitant may raise iloperidone concentrations, increasing QT and sedation risk, and iloperidone may slightly raise aprepitant levels.
How serious is the interaction between Aprepitant and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostasis and QT prolongation, with ECG and electrolytes if there are other risk factors. Consider reducing iloperidone dose if adverse effects emerge.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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