Drug interactions
Aprepitant + Itraconazole
Severity: Moderate
Aprepitant and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 inhibitor and increases aprepitant exposure considerably. This may increase aprepitant adverse effects, and aprepitant is a substrate whose labeling advises caution with strong inhibitors.
What this interaction means in plain words
Aprepitant and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Itraconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by itraconazole reduces aprepitant clearance.
What to do
Use with caution and monitor for aprepitant adverse effects, or choose an alternative antiemetic. No specific dose reduction is defined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Aprepitant with Itraconazole?
MediHelp rates the interaction as moderate. Aprepitant and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole is a strong CYP3A4 inhibitor and increases aprepitant exposure considerably. This may increase aprepitant adverse effects, and aprepitant is a substrate whose labeling advises caution with strong inhibitors.
How serious is the interaction between Aprepitant and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use with caution and monitor for aprepitant adverse effects, or choose an alternative antiemetic. No specific dose reduction is defined.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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