Drug interactions
Aprepitant + Lonafarnib
Severity: Major
Aprepitant and Lonafarnib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A4 substrate, and aprepitant is a moderate CYP3A4 inhibitor that can substantially raise lonafarnib exposure. This may increase toxicities such as gastrointestinal effects and electrolyte disturbances.
What this interaction means in plain words
Aprepitant and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Lonafarnib belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated lonafarnib metabolism by aprepitant.
What to do
Avoid the combination where possible and use an alternative antiemetic; if unavoidable, follow labeling for lonafarnib dose reduction and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Aprepitant with Lonafarnib?
MediHelp rates the interaction as major. Aprepitant and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib is a sensitive CYP3A4 substrate, and aprepitant is a moderate CYP3A4 inhibitor that can substantially raise lonafarnib exposure. This may increase toxicities such as gastrointestinal effects and electrolyte disturbances.
How serious is the interaction between Aprepitant and Lonafarnib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative antiemetic; if unavoidable, follow labeling for lonafarnib dose reduction and monitor for toxicity.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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