Drug interactions
Aprepitant + Lurasidone
Severity: Moderate
Aprepitant and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant increases lurasidone exposure, which may increase adverse effects such as akathisia, sedation, and parkinsonism.
What this interaction means in plain words
Aprepitant and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Lurasidone belongs to Central Nervous System.
Why it happens
Aprepitant inhibits CYP3A4, reducing lurasidone clearance.
What to do
Limit the lurasidone starting dose to 20 mg/day and the maximum to 80 mg/day while coadministered. Monitor for extrapyramidal effects and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Aprepitant with Lurasidone?
MediHelp rates the interaction as moderate. Aprepitant and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant increases lurasidone exposure, which may increase adverse effects such as akathisia, sedation, and parkinsonism.
How serious is the interaction between Aprepitant and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the lurasidone starting dose to 20 mg/day and the maximum to 80 mg/day while coadministered. Monitor for extrapyramidal effects and sedation.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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