Drug interactions
Aprepitant + Nisoldipine
Severity: Moderate
Aprepitant and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and can raise nisoldipine exposure, which is heavily dependent on CYP3A4 first-pass metabolism. This may cause excessive vasodilation with hypotension, flushing, headache and peripheral edema.
What this interaction means in plain words
Aprepitant and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Nisoldipine belongs to Cardiovascular.
Why it happens
Aprepitant inhibits intestinal and hepatic CYP3A4, reducing the metabolism of nisoldipine.
What to do
Monitor blood pressure and heart rate when aprepitant is given with nisoldipine, particularly over the multi-day aprepitant course. Reduce the nisoldipine dose if hypotension or edema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Aprepitant with Nisoldipine?
MediHelp rates the interaction as moderate. Aprepitant and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor and can raise nisoldipine exposure, which is heavily dependent on CYP3A4 first-pass metabolism. This may cause excessive vasodilation with hypotension, flushing, headache and peripheral edema.
How serious is the interaction between Aprepitant and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when aprepitant is given with nisoldipine, particularly over the multi-day aprepitant course. Reduce the nisoldipine dose if hypotension or edema occurs.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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