Drug interactions
Aprepitant + Rimegepant
Severity: Moderate
Aprepitant and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant raises rimegepant exposure, which may increase adverse effects.
What this interaction means in plain words
Aprepitant and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Rimegepant belongs to Central Nervous System.
Why it happens
Aprepitant inhibits CYP3A4, reducing rimegepant clearance.
What to do
Do not repeat a rimegepant dose within 48 hours when taken with aprepitant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Rimegepant
Frequently asked questions
Can I take Aprepitant with Rimegepant?
MediHelp rates the interaction as moderate. Aprepitant and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant raises rimegepant exposure, which may increase adverse effects.
How serious is the interaction between Aprepitant and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not repeat a rimegepant dose within 48 hours when taken with aprepitant.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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