Drug interactions
Aprepitant + Saxagliptin
Severity: Minor
Aprepitant and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saxagliptin is metabolised by CYP3A4/5 to an active metabolite, so aprepitant, a moderate inhibitor, may raise parent drug levels. The labeled dose limit applies to strong inhibitors, and the effect here is likely modest.
What this interaction means in plain words
Aprepitant and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Saxagliptin belongs to Endocrine.
Why it happens
Aprepitant inhibits CYP3A4, altering saxagliptin metabolism.
What to do
No routine adjustment is needed; monitor glycemic control and renal function as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Aprepitant with Saxagliptin?
MediHelp rates the interaction as minor. Aprepitant and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Saxagliptin is metabolised by CYP3A4/5 to an active metabolite, so aprepitant, a moderate inhibitor, may raise parent drug levels. The labeled dose limit applies to strong inhibitors, and the effect here is likely modest.
How serious is the interaction between Aprepitant and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor glycemic control and renal function as usual.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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