Drug interactions
Aprepitant + Solifenacin
Severity: Moderate
Aprepitant and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solifenacin is a CYP3A4 substrate, so aprepitant may increase its levels. This may worsen anticholinergic effects such as dry mouth, constipation, urinary retention and QT prolongation.
What this interaction means in plain words
Aprepitant and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Solifenacin belongs to Genitourinary.
Why it happens
Aprepitant inhibits CYP3A4 metabolism of solifenacin.
What to do
Monitor for anticholinergic effects and reduce the solifenacin dose if they become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Solifenacin
Frequently asked questions
Can I take Aprepitant with Solifenacin?
MediHelp rates the interaction as moderate. Aprepitant and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solifenacin is a CYP3A4 substrate, so aprepitant may increase its levels. This may worsen anticholinergic effects such as dry mouth, constipation, urinary retention and QT prolongation.
How serious is the interaction between Aprepitant and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and reduce the solifenacin dose if they become troublesome.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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