Drug interactions
Aprepitant + Voriconazole
Severity: Moderate
Aprepitant and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and may substantially increase aprepitant exposure. Higher aprepitant levels may raise adverse effects such as fatigue, headache and hiccups, and aprepitant could affect voriconazole minimally.
What this interaction means in plain words
Aprepitant and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, reducing aprepitant clearance.
What to do
Monitor for aprepitant adverse effects; no routine dose change is specified, but consider fosaprepitant single-dose regimens or alternatives if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Aprepitant with Voriconazole?
MediHelp rates the interaction as moderate. Aprepitant and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4 and may substantially increase aprepitant exposure. Higher aprepitant levels may raise adverse effects such as fatigue, headache and hiccups, and aprepitant could affect voriconazole minimally.
How serious is the interaction between Aprepitant and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aprepitant adverse effects; no routine dose change is specified, but consider fosaprepitant single-dose regimens or alternatives if tolerability is poor.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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