Drug interactions
Argatroban + Liothyronine
Severity: Minor
Argatroban and Liothyronine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormones can increase the catabolism of vitamin K-dependent clotting factors, which enhances the effect of oral anticoagulants. With argatroban, a direct thrombin inhibitor, a clinically significant interaction is not well documented.
What this interaction means in plain words
Argatroban and Liothyronine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Argatroban belongs to Cardiovascular; Liothyronine belongs to Endocrine.
Why it happens
Not established for argatroban; thyroid hormone accelerates clotting factor catabolism, an effect relevant mainly to vitamin K antagonists.
What to do
No dose adjustment is needed. Follow the aPTT during argatroban therapy as usual, particularly when thyroid hormone doses change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Argatroban with Liothyronine?
MediHelp rates the interaction as minor. Argatroban and Liothyronine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thyroid hormones can increase the catabolism of vitamin K-dependent clotting factors, which enhances the effect of oral anticoagulants. With argatroban, a direct thrombin inhibitor, a clinically significant interaction is not well documented.
How serious is the interaction between Argatroban and Liothyronine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Follow the aPTT during argatroban therapy as usual, particularly when thyroid hormone doses change.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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