Drug interactions
Aripiprazole + Enzalutamide
Severity: Major
Aripiprazole and Enzalutamide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and also induces CYP2D6-independent clearance pathways, lowering aripiprazole exposure. This can lead to loss of antipsychotic efficacy and relapse.
What this interaction means in plain words
Aripiprazole and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, increasing the metabolism of aripiprazole.
What to do
Labeling advises doubling the aripiprazole dose when a strong CYP3A4 inducer is added, with reduction back to the usual dose if the inducer is stopped. Monitor psychiatric response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Aripiprazole with Enzalutamide?
MediHelp rates the interaction as major. Aripiprazole and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is a strong CYP3A4 inducer and also induces CYP2D6-independent clearance pathways, lowering aripiprazole exposure. This can lead to loss of antipsychotic efficacy and relapse.
How serious is the interaction between Aripiprazole and Enzalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Labeling advises doubling the aripiprazole dose when a strong CYP3A4 inducer is added, with reduction back to the usual dose if the inducer is stopped. Monitor psychiatric response closely.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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