Drug interactions
Aripiprazole + Lisdexamfetamine
Severity: Minor
Aripiprazole and Lisdexamfetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole is often used to counter stimulant-related psychosis or agitation, and may reduce the alerting effect of stimulants. Aripiprazole is also a partial dopamine agonist, so the pharmacodynamic opposition is generally manageable and usually not harmful.
What this interaction means in plain words
Aripiprazole and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic CNS effects: dopamine and norepinephrine release by amphetamine versus dopamine partial agonism and antagonism.
What to do
No routine adjustment is needed. Monitor therapeutic response and for agitation or akathisia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Lisdexamfetamine?
MediHelp rates the interaction as minor. Aripiprazole and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aripiprazole is often used to counter stimulant-related psychosis or agitation, and may reduce the alerting effect of stimulants. Aripiprazole is also a partial dopamine agonist, so the pharmacodynamic opposition is generally manageable and usually not harmful.
How serious is the interaction between Aripiprazole and Lisdexamfetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor therapeutic response and for agitation or akathisia.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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