Drug interactions
Aripiprazole + Prochlorperazine
Severity: Moderate
Aripiprazole and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents block dopamine receptors, so together they increase the risk of extrapyramidal symptoms, akathisia and rarely neuroleptic malignant syndrome. Sedation and orthostatic hypotension may also be additive.
What this interaction means in plain words
Aripiprazole and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive dopamine D2 receptor antagonism or partial agonism plus additive CNS depression.
What to do
Monitor for movement disorders, rigidity, fever and sedation; use the lowest effective doses and avoid prolonged duplicate antipsychotic therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Prochlorperazine?
MediHelp rates the interaction as moderate. Aripiprazole and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents block dopamine receptors, so together they increase the risk of extrapyramidal symptoms, akathisia and rarely neuroleptic malignant syndrome. Sedation and orthostatic hypotension may also be additive.
How serious is the interaction between Aripiprazole and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for movement disorders, rigidity, fever and sedation; use the lowest effective doses and avoid prolonged duplicate antipsychotic therapy.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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