Drug interactions
Aripiprazole + Toremifene
Severity: Major
Aripiprazole and Toremifene: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene causes dose-related QT prolongation and aripiprazole may add a small effect. Torsades de pointes is a concern, especially with electrolyte disturbance or other risk factors.
What this interaction means in plain words
Aripiprazole and Toremifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Toremifene belongs to Endocrine.
Why it happens
Additive effects on cardiac repolarization.
What to do
Avoid if possible. If combined, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Abilify 1 mg/mL Oral Solution - SmPC sections 4.3/4.5 (class statement: medicinal products known to cause QT prolongation; "If aripiprazole is administered concomitantly with medicinal products known to cause QT prolongation or electrolyte imbalance, caution should be used.") — electronic medicines compendium (UK SmPC)
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Aripiprazole with Toremifene?
MediHelp rates the interaction as major. Aripiprazole and Toremifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Toremifene causes dose-related QT prolongation and aripiprazole may add a small effect. Torsades de pointes is a concern, especially with electrolyte disturbance or other risk factors.
How serious is the interaction between Aripiprazole and Toremifene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If combined, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc regularly.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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