Drug interactions
Aripiprazole + Vilazodone
Severity: Moderate
Aripiprazole and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone is a serotonergic antidepressant and aripiprazole is often added as an augmenting agent. The combination is used clinically but carries a small risk of serotonin syndrome or neuroleptic malignant syndrome, and aripiprazole levels may rise slightly.
What this interaction means in plain words
Aripiprazole and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic and dopaminergic modulation; vilazodone may mildly inhibit CYP2D6 and affect aripiprazole exposure.
What to do
Monitor for mental status change, tremor, hyperthermia, rigidity and autonomic instability, especially after dose changes. Adjust aripiprazole if akathisia or other adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Vilazodone?
MediHelp rates the interaction as moderate. Aripiprazole and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilazodone is a serotonergic antidepressant and aripiprazole is often added as an augmenting agent. The combination is used clinically but carries a small risk of serotonin syndrome or neuroleptic malignant syndrome, and aripiprazole levels may rise slightly.
How serious is the interaction between Aripiprazole and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, tremor, hyperthermia, rigidity and autonomic instability, especially after dose changes. Adjust aripiprazole if akathisia or other adverse effects emerge.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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