Drug interactions
Armodafinil + Bupropion-naltrexone
Severity: Minor
Armodafinil and Bupropion-naltrexone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may induce enzymes involved in bupropion metabolism, potentially lowering parent bupropion levels while changing the ratio of its active metabolites. The clinical effect on efficacy or tolerability is uncertain.
What this interaction means in plain words
Armodafinil and Bupropion-naltrexone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Bupropion-naltrexone belongs to Miscellaneous.
Why it happens
Possible induction of CYP-mediated metabolism by armodafinil, altering bupropion and metabolite concentrations.
What to do
No routine dose change is needed; monitor clinical response and tolerability of bupropion.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Bupropion-naltrexone?
MediHelp rates the interaction as minor. Armodafinil and Bupropion-naltrexone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil may induce enzymes involved in bupropion metabolism, potentially lowering parent bupropion levels while changing the ratio of its active metabolites. The clinical effect on efficacy or tolerability is uncertain.
How serious is the interaction between Armodafinil and Bupropion-naltrexone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor clinical response and tolerability of bupropion.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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