Drug interactions
Armodafinil + Cinacalcet
Severity: Minor
Armodafinil and Cinacalcet: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is metabolised by CYP3A4, CYP2D6 and CYP1A2, and armodafinil is a weak CYP3A4 inducer. Cinacalcet exposure may fall slightly, though a clinically meaningful change is unlikely.
What this interaction means in plain words
Armodafinil and Cinacalcet have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Cinacalcet belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by armodafinil increases cinacalcet metabolism.
What to do
No empirical dose change is required. Monitor serum calcium and PTH after starting or stopping armodafinil.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Armodafinil with Cinacalcet?
MediHelp rates the interaction as minor. Armodafinil and Cinacalcet have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cinacalcet is metabolised by CYP3A4, CYP2D6 and CYP1A2, and armodafinil is a weak CYP3A4 inducer. Cinacalcet exposure may fall slightly, though a clinically meaningful change is unlikely.
How serious is the interaction between Armodafinil and Cinacalcet?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required. Monitor serum calcium and PTH after starting or stopping armodafinil.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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