Drug interactions
Armodafinil + Cinnarizine
Severity: Minor
Armodafinil and Cinnarizine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine is a sedating antihistamine and calcium channel blocker, while armodafinil promotes wakefulness. The opposing effects may blunt the therapeutic effect of either drug, and the net effect on alertness is unpredictable.
What this interaction means in plain words
Armodafinil and Cinnarizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Cinnarizine belongs to Respiratory.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no pharmacokinetic interaction is established.
What to do
No dose change is routinely needed; monitor daytime alertness and adjust the dose of the wake-promoting or sedating agent if sedation or insomnia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Armodafinil with Cinnarizine?
MediHelp rates the interaction as minor. Armodafinil and Cinnarizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cinnarizine is a sedating antihistamine and calcium channel blocker, while armodafinil promotes wakefulness. The opposing effects may blunt the therapeutic effect of either drug, and the net effect on alertness is unpredictable.
How serious is the interaction between Armodafinil and Cinnarizine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor daytime alertness and adjust the dose of the wake-promoting or sedating agent if sedation or insomnia develops.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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