Drug interactions
Armodafinil + Clarithromycin
Severity: Minor
Armodafinil and Clarithromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is partly metabolized by CYP3A4, so clarithromycin may raise its levels. Any effect is likely modest, with possible increases in headache, anxiety or insomnia.
What this interaction means in plain words
Armodafinil and Clarithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Clarithromycin belongs to Anti Bacterial.
Why it happens
CYP3A4 inhibition by clarithromycin reduces armodafinil metabolism.
What to do
No dose adjustment is generally needed; monitor for increased adverse effects such as insomnia, anxiety and headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Clarithromycin?
MediHelp rates the interaction as minor. Armodafinil and Clarithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is partly metabolized by CYP3A4, so clarithromycin may raise its levels. Any effect is likely modest, with possible increases in headache, anxiety or insomnia.
How serious is the interaction between Armodafinil and Clarithromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for increased adverse effects such as insomnia, anxiety and headache.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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