Drug interactions
Armodafinil + Clomipramine
Severity: Minor
Armodafinil and Clomipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may weakly induce CYP enzymes and lower clomipramine levels, and modafinil-type drugs have also been linked to raised tricyclic levels via CYP2C19 inhibition. The net effect is unpredictable but usually small.
What this interaction means in plain words
Armodafinil and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Clomipramine belongs to Central Nervous System.
Why it happens
Mixed weak effects on CYP enzymes; the net effect on clomipramine is not well established.
What to do
Monitor clinical response and tricyclic adverse effects when starting or stopping armodafinil, and adjust the clomipramine dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Clomipramine?
MediHelp rates the interaction as minor. Armodafinil and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil may weakly induce CYP enzymes and lower clomipramine levels, and modafinil-type drugs have also been linked to raised tricyclic levels via CYP2C19 inhibition. The net effect is unpredictable but usually small.
How serious is the interaction between Armodafinil and Clomipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and tricyclic adverse effects when starting or stopping armodafinil, and adjust the clomipramine dose accordingly.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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