Drug interactions
Armodafinil + Clorazepate
Severity: Minor
Armodafinil and Clorazepate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil promotes wakefulness and may partly offset clorazepate-related drowsiness, but it does not reliably reverse impairment. Armodafinil is also a weak CYP3A4 inducer and may modestly lower clorazepate metabolite levels, which could reduce anxiolytic or anticonvulsant effect.
What this interaction means in plain words
Armodafinil and Clorazepate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Clorazepate belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on alertness, with weak CYP3A4 induction by armodafinil.
What to do
Do not rely on armodafinil to counter benzodiazepine sedation. Monitor clinical response to clorazepate and adjust the dose if efficacy appears reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Clorazepate?
MediHelp rates the interaction as minor. Armodafinil and Clorazepate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil promotes wakefulness and may partly offset clorazepate-related drowsiness, but it does not reliably reverse impairment. Armodafinil is also a weak CYP3A4 inducer and may modestly lower clorazepate metabolite levels, which could reduce anxiolytic or anticonvulsant effect.
How serious is the interaction between Armodafinil and Clorazepate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on armodafinil to counter benzodiazepine sedation. Monitor clinical response to clorazepate and adjust the dose if efficacy appears reduced.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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