Drug interactions
Armodafinil + Crizotinib
Severity: Moderate
Armodafinil and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and may raise armodafinil concentrations, since armodafinil is partly cleared by CYP3A4. This could increase adverse effects such as headache, anxiety, insomnia and raised blood pressure.
What this interaction means in plain words
Armodafinil and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, reducing armodafinil metabolism.
What to do
Monitor for armodafinil adverse effects such as insomnia, anxiety and hypertension, and reduce the armodafinil dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Armodafinil with Crizotinib?
MediHelp rates the interaction as moderate. Armodafinil and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and may raise armodafinil concentrations, since armodafinil is partly cleared by CYP3A4. This could increase adverse effects such as headache, anxiety, insomnia and raised blood pressure.
How serious is the interaction between Armodafinil and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for armodafinil adverse effects such as insomnia, anxiety and hypertension, and reduce the armodafinil dose if they occur.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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