Drug interactions
Armodafinil + Darunavir
Severity: Moderate
Armodafinil and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may lower darunavir exposure by weak CYP3A4 induction. Darunavir is usually boosted with ritonavir or cobicistat, which may offset much of this effect, but reduced antiviral activity remains possible.
What this interaction means in plain words
Armodafinil and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Darunavir belongs to Anti Virals.
Why it happens
Armodafinil induces CYP3A4, increasing darunavir metabolism.
What to do
Monitor HIV viral load and clinical response. Consider checking drug levels if virologic control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Armodafinil and Darunavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Armodafinil
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Armodafinil with Darunavir?
MediHelp rates the interaction as moderate. Armodafinil and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may lower darunavir exposure by weak CYP3A4 induction. Darunavir is usually boosted with ritonavir or cobicistat, which may offset much of this effect, but reduced antiviral activity remains possible.
How serious is the interaction between Armodafinil and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and clinical response. Consider checking drug levels if virologic control worsens.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
