Drug interactions
Armodafinil + Dasatinib
Severity: Moderate
Armodafinil and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak to moderate CYP3A4 inducer and could lower dasatinib exposure, potentially reducing its efficacy in leukemia. The effect is smaller than with strong inducers.
What this interaction means in plain words
Armodafinil and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Dasatinib belongs to Oncology.
Why it happens
Induction of CYP3A4 increases dasatinib metabolism.
What to do
Monitor hematologic and molecular response to dasatinib, and consider an alternative to armodafinil if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Armodafinil with Dasatinib?
MediHelp rates the interaction as moderate. Armodafinil and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil is a weak to moderate CYP3A4 inducer and could lower dasatinib exposure, potentially reducing its efficacy in leukemia. The effect is smaller than with strong inducers.
How serious is the interaction between Armodafinil and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hematologic and molecular response to dasatinib, and consider an alternative to armodafinil if response is inadequate.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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