Drug interactions
Armodafinil + Dexchlorpheniramine
Severity: Minor
Armodafinil and Dexchlorpheniramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil promotes wakefulness while dexchlorpheniramine, a sedating antihistamine, causes drowsiness. The effects oppose one another and no meaningful harmful interaction is established.
What this interaction means in plain words
Armodafinil and Dexchlorpheniramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Dexchlorpheniramine belongs to Respiratory.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no established pharmacokinetic interaction.
What to do
No specific action is needed. Counsel the patient that the sedation from the antihistamine may be only partly masked.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Armodafinil with Dexchlorpheniramine?
MediHelp rates the interaction as minor. Armodafinil and Dexchlorpheniramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil promotes wakefulness while dexchlorpheniramine, a sedating antihistamine, causes drowsiness. The effects oppose one another and no meaningful harmful interaction is established.
How serious is the interaction between Armodafinil and Dexchlorpheniramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Counsel the patient that the sedation from the antihistamine may be only partly masked.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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