Drug interactions
Armodafinil + Etravirine
Severity: Moderate
Armodafinil and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may weakly induce CYP3A4, lowering etravirine levels, and may weakly inhibit CYP2C19, which could raise them. The net effect is uncertain and probably small.
What this interaction means in plain words
Armodafinil and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Etravirine belongs to Anti Virals.
Why it happens
Opposing effects of weak CYP3A4 induction and CYP2C19 inhibition by armodafinil on etravirine metabolism.
What to do
Monitor HIV viral load and clinical response, as well as tolerability of etravirine, when armodafinil is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Armodafinil with Etravirine?
MediHelp rates the interaction as moderate. Armodafinil and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may weakly induce CYP3A4, lowering etravirine levels, and may weakly inhibit CYP2C19, which could raise them. The net effect is uncertain and probably small.
How serious is the interaction between Armodafinil and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and clinical response, as well as tolerability of etravirine, when armodafinil is started or stopped.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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