Drug interactions
Armodafinil + Flibanserin
Severity: Minor
Armodafinil and Flibanserin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is generally described as a weak CYP3A4 inducer, although it also has some inhibitory effects on CYP2C19. The net effect on flibanserin exposure is uncertain. Flibanserin can cause sedation, hypotension and syncope, so any change in exposure matters.
What this interaction means in plain words
Armodafinil and Flibanserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Flibanserin belongs to Genitourinary.
Why it happens
Possible weak modulation of CYP3A4 and CYP2C19 metabolism of flibanserin; the net direction is not well established.
What to do
No dose adjustment is usually needed. Monitor for reduced response or increased dizziness and sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Flibanserin?
MediHelp rates the interaction as minor. Armodafinil and Flibanserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is generally described as a weak CYP3A4 inducer, although it also has some inhibitory effects on CYP2C19. The net effect on flibanserin exposure is uncertain. Flibanserin can cause sedation, hypotension and syncope, so any change in exposure matters.
How serious is the interaction between Armodafinil and Flibanserin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for reduced response or increased dizziness and sedation.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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