Drug interactions
Armodafinil + Fluphenazine
Severity: Minor
Armodafinil and Fluphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine is sedating, while armodafinil promotes wakefulness, so their effects on alertness oppose each other. Armodafinil may also cause psychiatric adverse effects such as anxiety or psychosis in susceptible patients.
What this interaction means in plain words
Armodafinil and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Fluphenazine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic CNS effects; no established pharmacokinetic mechanism.
What to do
Monitor psychiatric status and alertness when combining them.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Armodafinil with Fluphenazine?
MediHelp rates the interaction as minor. Armodafinil and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluphenazine is sedating, while armodafinil promotes wakefulness, so their effects on alertness oppose each other. Armodafinil may also cause psychiatric adverse effects such as anxiety or psychosis in susceptible patients.
How serious is the interaction between Armodafinil and Fluphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric status and alertness when combining them.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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